His research has centered on understanding the mechanisms by which the human immune system recognises the Mycobacterium tuberculosis M. His work has a strong translational component, asking if both classically and non-classically restricted T cells are associated with infection with M.
The translational significance of this research is centred on informing the development of novel vaccines and diagnostics for childhood TB. Her current research focuses on HIV broadly neutralising antibodies and their interplay with the evolving virus.
Recent studies published in PloS Pathogens, Nature and Nature Medicine have highlighted the role of viral escape in creating new epitopes and immunotypes, thereby driving the development of neutralisation breadth, with implications for HIV vaccine design.
Research interest in tuberculosis and in developing and testing point of care diagnostics suitable for the developing world. Male operator in Bangalore selling a credit card he could never afford himself: "This card comes to you with one of the lowest APR. Woman operator in Bangalore explaining to an American how she screwed up her checking account: "Check number six-six-five for eighty-one dollars and fifty-five cents.
You will still be hit by the thirty-dollar charge. Am I clear? Woman operator in Bangalore after walking an American through a computer glitch: "Not a problem, Mr. Thank you for your time. Take care. Woman operator in Bangalore after someone has just slammed down the phone on her: "Hello? Woman operator in Bangalore apologizing for calling someone in America too early:"This is just a courtesy call, I'll call back later in the evening. Male operator in Bangalore trying desperately to sell an airline credit card to someone in America who doesn't seem to want one: "Is that because you have too many credit cards, or you don't like flying, Mrs.
Woman operator in Bangalore trying to talk an American out of her computer crash: "Start switching between memory okay and memory test. Male operator in Bangalore doing the same thing: "All right, then, let's just punch in three and press Enter. Woman operator in Bangalore trying to help an American who cannot stand being on the help line another second: "Yes, ma'am, I do understand that you are in a hurry right now.
I am just trying to help you out. Woman operator in Bangalore getting another phone slammed down on her: "Yes, well, so what time would be goo. Same woman operator in Bangalore getting another phone slammed down on her: "Why, Mrs. Kent, it's not a Same woman operator in Bangalore getting another phone slammed down on her: "As a safety back. Same woman operator in Bangalore looking up from her phone: "I definitely have a bad.
Woman operator in Bangalore trying to help an American woman with a computer problem that she has never heard before: "What is the problem with this machine, ma'am? The monitor is burning? There are currently about , Indians answering phones from all over the world or dialing out to solicit people for credit cards or cell phone bargains or overdue bills. These call center jobs are low-wage, low-prestige jobs in America, but when shifted to India they become high-wage, high-prestige jobs.
They would call in because they had lost their wallet or just to talk to somebody. I'm like, 'Okay, all right, maybe you should look under the bed [for your wallet] or where do you normally keep it,' and she's like, 'Okay, thank you so much for helping. She had traveled two connecting flights and she lost her bag and in the bag was her daughter's wedding gown and wedding ring and I felt so sad for her and there was nothing I could do.
I had no information. I want my bag now! We are supposed to tell the truth, [so] we tell them India. Some thought it was Indiana, not India!
Some did not know where India is. I said it is the country next to Pakistan. Although the great majority of the calls are rather routine and dull, competition for these jobs is fierce-not only because they pay well, but because you can work at night and go to school during part of the day, so they are stepping-stones toward a higher standard of living.
We also provide transportation, lunch, and dinner at no extra cost. We provide life insurance, medical insurance for the entire family- and other benefits. Everyone is also entitled to performance bonuses that allow them to earn, in certain cases, the equivalent of percent of their base salary. We sponsor an MBA program for consistent performers [with] full-day classes over the weekend. Everyone works eight hours a day, five days a week, with two fifteen-minute breaks and an hour off for lunch or dinner.
Here is a snippet from a recruiting session for call center operators at a women's college in Bangalore: Recruiter 1: "Good morning, girls. The primary clients that we are recruiting [for] today are Honeywell.
And also for America Online. The young women-dozens of them-then all lined up with their application forms and waited to be interviewed by a recruiter at a wooden table. Here is what some of the interviews sounded like:. Applicant 1: "It should be based on accounts, then, where I can grow, I can grow in my career. Recruiter 1: "You have to be more confident about yourself when you're speaking. You're very nervous.
I want you to work a little on that and then get in touch with us. Recruiter 2 to another applicant: "Tell me something about yourself. Applicant 2: "I have passed my SSC with distinction. Second P also with distinction. And I also hold a 70 percent aggregate in previous two years.
Recruiter 2: "Go a little slow. Don't be nervous. Be cool. The next step for those applicants who are hired at a call center is the training program, which they are paid to attend. It combines learning how to handle the specific processes for the company whose calls they will be taking or making, and attending something called "accent neutralization class. It's pretty bizarre to watch. The class I sat in on was being trained to speak in a neutral middle-American accent.
The students were asked to read over and over a single phonetic paragraph designed to teach them how to soften their r's and to roll their r's. Their teacher, a charming eight-months-pregnant young woman dressed in a traditional Indian sari, moved seamlessly among British, American, and Canadian accents as she demonstrated reading a paragraph designed to highlight phonetics.
She said to the class, "Remember the first day I told you that the Americans flap the 'tuh' sound? You know, it sounds like an almost 'duh' sound-not crisp and clear like the British. So I would not say"-here she was crisp and sharp-'"Betty bought a bit of better butter' or 'Insert a quarter in the meter. All right? A bottle of bottled water held thirty little turtles.
It didn't matter that each turtle had to rattle a metal ladle in order to get a little bit of noodles. Each member of the class then took a turn trying to say this tongue twister in an American accent. Some of them got it on the first try, and others, well, let's just say that you wouldn't think they were in Kansas City if they answered your call to Delta's lost-luggage number.
After listening to them stumble through this phonetics lesson for half an hour, I asked the teacher if she would like me to give them an authentic version-since I'm originally from Minnesota, smack in the Midwest, and still speak like someone out of the movie Fargo. Absolutely, she said. So I read the following paragraph: "A bottle of bottled water held thirty little turtles. It didn't matter that each turtle had to rattle a metal ladle in order to get a little bit of noodles, a total turtle delicacy.
The problem was that there were many turtle battles for less than oodles of noodles. Every time they thought about grappling with the haggler turtles their little turtle minds boggled and they only caught a little bit of noodles. The class responded enthusiastically. It was the first time I ever got an ovation for speaking Minnesotan. On the surface, there is something unappealing about the idea of inducing other people to flatten their accents in order to compete in a flatter world.
But before you disparage it, you have to taste just how hungry these kids are to escape the lower end of the middle class and move up. If a little accent modification is the price they have to pay to jump a rung of the ladder, then so be it-they say. You work in the day, and then the night, and then the next morning. It is the tension of success.
They are dealing with the challenges of success, of high-pressure living. It is not the challenge of worrying about whether they would have a challenge. That was certainly the sense I got from talking to a lot of the call center operators on the floor.
Like any explosion of modernity, outsourcing is challenging traditional norms and ways of life. But educated Indians have been held back so many years by both poverty and a socialist bureaucracy that many of them seem more than ready to put up with the hours. And needless to say, it is much easier and more satisfying for them to work hard in Bangalore than to pack up and try to make a new start in America.
In the flat world they can stay in India, make a decent salary, and not have to be away from families, friends, food, and culture. At the end of the day, these new jobs actually allow them to be more Indian.
But I couldn't go because I couldn't afford it. I didn't have the money for it. Now I can, [but] I see a whole lot of American industry has come into Bangalore and I don't really need to go there. I can work for a multinational sitting right here.
So I still get my rice and sam-bar [a traditional Indian dish], which I eat. I don't need to, you know, learn to eat coleslaw and cold beef. I still continue with my Indian food and I still work for a multinational. Why should I go to America?
The chips are designed by Intel. The phones are from Lucent. The air-conditioning is by Carrier, and even the bottled water is by Coke. So even with the outsourcing of some service jobs from the United States to India, India's growing economy is creating a demand for many more American goods and services.
What goes around, comes around. Nine years ago, when Japan was beating America's brains out in the auto industry, I wrote a column about playing the computer geography game Where in the World is Carmen Sandiego?
I was trying to help her by giving her a clue suggesting that Carmen had gone to Detroit, so I asked her, "Where are cars made? Well, I was reminded of that story while visiting Global Edge, an Indian software design firm in Bangalore. The company's marketing manager, , told me that he had just made a cold call to the VP for engineering of a U.
As soon as Mr. Rao introduced himself as calling from an Indian software firm, the U. Said Mr. Rao, "A few years ago nobody in America wanted to talk to us. Now they are eager. So now I wonder: If I have a granddaughter one day, and I tell her I'm going to India, will she say, "Grandpa, is that where software comes from? No, not yet, honey. Every new product-from software to widgets-goes through a cycle that begins with basic research, then applied research, then incubation, then development, then testing, then manufacturing, then deployment, then support, then continuation engineering in order to add improvements.
Each of these phases is specialized and unique, and neither India nor China nor Russia has a critical mass of talent that can handle the whole product cycle for a big American multinational. But these countries are steadily developing their reseach and development capabilities to handle more and more of these phases.
As that continues, we really will see the beginning of what Satyam Cherukuri, of Sarnoff, an American research and development firm, has called "the globalization of innovation" and an end to the old model of a single American or European multinational handling all the elements of the development product cycle from its own resources. More and more American and European companies are outsourcing significant research and development tasks to India, Russia, and China.
Patent Office. Texas Instruments alone has had U. Welch Technology Centre in Bangalore, engineers are developing new ideas for aircraft engines, transport systems and plastics. GE now even sends non-Indians to Bangalore. Vivek Paul is the president of Wipro Technologies, another of the elite Indian technology companies, but he is based in Silicon Valley to be close to Wipro's American customers. At the time he had a French colleague who managed GE's power generator business for the scanners out of France.
That is a flat world. Every time I think I have found the last, most obscure job that could be outsourced to Bangalore, I discover a new one. My friend Vivek Kulkarni used to head the government office in Bangalore responsible for attracting high technology global investment. After stepping down from that post in , he started a company called B2K, with a division called Brickwork, which offers busy global executives their own personal assistant in India.
Say you are running a company and you have been asked to give a speech and a PowerPoint presentation in two days. Your "remote executive assistant" in India, provided by Brickwork, will do all the research for you, create the PowerPoint presentation, and e-mail the whole thing to you overnight so that it is on your desk the day you have to deliver it.
When you wake up, you will find the completed summary in your in-box. As Brickwork's promotional material says, "India's talent pool provides companies access to a broad spectrum of highly qualified people. In addition to fresh graduates, which are around 2.
One is American health-care consultants, who often need lots of numbers crunched and PowerPoint presentations drawn up. The other, he said, are American investment banks and financial services companies, which often need to prepare glossy pamphlets with graphs to illustrate the benefits of an IPO or a proposed merger.
In the case of a merger, Brickwork will prepare those sections of the report dealing with general market conditions and trends, where most of the research can be gleaned off the Web and summarized in a standard format.
They are full of ambition to do their higher problem solving as well, said Kulkarni. You are always taking an examination. There is no end to learning. There is no real end to what can be done by whom. Unlike Columbus, I didn't stop with India. After I got home, I decided to keep exploring the East for more signs that the world was flat.
And what do they do? Not consulting anymore,explained Ohmae. He is now spearheading a drive to outsource low-end Japanese jobs to Japanese-speaking call centers and service providers in China. Didn't the Japanese once colonize China, leaving a very bad taste in the mouths of the Chinese? Well, yes, said Ohmae, but he explained that the Japanese also left behind a large number of Japanese speakers who have maintained a slice of Japanese culture, from sushi to karaoke, in northeastern China, particularly around the northeastern port city of Dalian.
Dalian has become for Japan what Bangalore has become for America and the other English-speaking countries: outsourcing central.
The Chinese may never forgive Japan for what it did to China in the last century, but the Chinese are so focused on leading the world in the next century that they are ready to brush up on their Japanese and take all the work Japan can outsource.
So all of these Japanese companies are coming in. Ohmae's company has developed a software program that takes the data to be entered and breaks it down into packets.
These packets can then be sent around China or Japan for typing, depending on the specialty required, and then reassembled at the company's database in its Tokyo headquarters.
The firm has recently expanded into computer-aided designs for a Japanese housing company. Maybe there is hope for this flat world. Dalian is impressive not just for a Chinese city. With its wide boulevards, beautiful green spaces, and nexus of universities, technical colleges, and massive software park, Dalian would stand out in Silicon Valley.
I had been here in , but there had been so much new building since then that I did not recognize the place. Dalian, which is located about an hour's flight northeast of Beijing, symbolizes how rapidly China's most modern cities-and there are still plenty of miserable, backward ones-are grabbing business as knowledge centers, not just as manufacturing hubs.
The signs on the buildings tell the whole story: GE, Microsoft, Dell, SAP, HP, Sony, and Accenture- to name but a few-all are having backroom work done here to support their Asian operations, as well as new software research and development.
Because of its proximity to Japan and Korea, each only about an hour away by air, its large number of Japanese speakers, its abundance of Internet bandwidth, and many parks and a world-class golf course all of which appeal to knowledge workers , Dalian has become an attractive locus for Japanese outsourcing.
No wonder some twenty-eight hundred Japanese companies have set up operations here or teamed up with Chinese partners. For a Communist authoritarian system, China does a pretty good job of promoting people on merit. The Mandarin meritocratic culture here still runs very deep. Over a traditional ten-course Chinese dinner at a local hotel, the mayor told me how far Dalian has come and just where he intends to take it. More than half those students graduate with engineering or science degrees, and even those who don't, those who study history or literature, are still being directed to spend a year studying Japanese or English, plus computer science, so that they will be employable.
The mayor estimated that more than half the residents of Dalian had access to the Internet at the office, home, or school. In the past one or two years, the software companies of the U. We are approaching and we are catching up with the Indians.
Exports of software products [from Dalian] have been increasing by 50 percent annually. And China is now becoming the country that develops the largest number of university graduates.
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In The Name Of Love [] The Righteous Brothers - Unchained Melody [] Herman's Hermits - Silhouettes [] The Byrds - Mr. Tambourine Man [] Barbara Mason - Yes. I'm Ready []
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